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Drug Names(s): Ad-PPE-Fas-c, GT-111, VB-111
Description: VB-111 is a tissue and condition specific vascular disrupting and anti-angiogenic agent based on a novel Vascular Targeting System (VTS) which contains the modified angiogenic specific pre-proendothelin promoter (PPE), and a FAS/TNF receptor chimeric transgene (Fas-C). The Fas-c protein is an engineered protein made of two parts: a part of a receptor called ‘TNF receptor’ to which a ligand, TNF-alpha, attaches, as well as a part of the Fas protein which activates cell death. When TNF-alpha attaches to the Fas-c protein, the Fas component of the protein is expected to cause the death of the developing blood vessels. As a result, the medicine is expected to stop the formation of new blood vessels which will prevent the growth of a tumor.
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