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U3-1565

Daiichi Sankyo Co., Ltd.

Drug Names(s): U3 1565

Description: U3-1565 is a fully human monoclonal antibody directed against human heparin-binding epidermal growth factor-like growth factor (HB-EGF) a member of the EGF family of ligands that bind to and activate the EGFR and HER4. HB-EGF-mediated activation of its target receptors results in oncogenic signaling.

Deal Structure: In June 2002, U3 Pharma and Abgenix announced the formation of a collaboration to discover, develop and potentially commercialize fully human monoclonal antibody therapies directed against, validated proprietary drug targets selected from U3 Pharma's portfolio, including U3-1287. Both parties will conduct in vitro and in vivo studies of the antibody candidates. Subsequently, Abgenix and U3 Pharma will have the right to co-develop and commercialize antibody products discovered during the collaboration. The parties will share equally in the development costs and any potential profits from sales of any co-developed products.

In April 2006, Amgen completed its acquisition of Abgenix.

In May 2008, Daiichi Sankyo announced that it entered into an agreement to acquire U3 Pharma.

Partners: Amgen, Inc.


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