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Brazikumab

Allergan plc

Drug Names(s): MEDI-2070, AMG 139

Description: Revenue splits are BioMedTracker estimates.

AMG 139 is an anti-IL-23 fully human monoclonal antibody.

Deal Structure: Amgen and AstraZeneca
In April 2012, Amgen and AstraZeneca announced an agreement to jointly develop and commercialize five monoclonal antibodies from Amgen's clinical inflammation portfolio: AMG 139, AMG 157, AMG 181, AMG 557 and brodalumab (AMG 827).

Under the terms of the agreement, AstraZeneca will make a one-time $50 million upfront payment and the companies will share both costs and profits. Based on current plans, approximately 65 percent of costs for the 2012-2014 period will be funded by AstraZeneca. Thereafter, the companies will split costs equally. Amgen will book sales globally and will retain a low single-digit royalty for brodalumab and a mid single-digit royalty for the rest of the portfolio, after which the companies will share profits equally.

AstraZeneca will lead the development and commercial strategy of AMG 139, AMG 157 and AMG 181, while Amgen will lead the development and commercial strategy of brodalumab and AMG 557. Each development and...See full deal structure in Biomedtracker

Partners: Amgen, Inc. AstraZeneca PLC


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