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Ionis Pharmaceuticals, Inc.

Drug Names(s): ISIS-PTP1BRx, ISIS 404173, IONIS-PTP1B Rx

Description: ISIS-PTP1BRx is an antisense drug that inhibits the production of protein tyrosine phosphatase-1B (PTP-1B), a protein that negatively regulates insulin receptor signaling. PTP-1B is responsible for turning off the activated insulin receptor, so reducing PTP-1B enhances insulin activity.

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