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Merck & Co., Inc.

Drug Names(s): Libivirumab and Exbivirumab for injection

Description: HepeX-B is a mixture of two human monoclonal antibodies directed against different epitopes on the surface antigen of the hepatitis B virus (HBV). It is currently being evaluated for its anti-viral activity in clinical studies.

Deal Structure: In June 2004, Cubist signed an agreement with XTL Biopharmaceuticals Ltd under which XTL granted to Cubist an exclusive, worldwide license (with the right to sub-license) to commercialize HepeX-B. Cubist is responsible for completing the development and for registration and commercialization of the product worldwide. XTL will receive milestone payments and is entitled to receive royalties from net sales by Cubist, if any, generally ranging from 10% to 17%, depending on levels of net sales achieved by Cubist, subject to certain deductions based on patent protection of HepeX-B in that territory, total cost of HepeX-B development, third party license payments and indemnification obligations.

On September 20, 2005, XOMA Ltd. signed a letter agreement with Cubist to develop new processes to manufacture HepeX-B. Specifically, the letter agreement calls for XOMA to develop commercial processes for the manufacture of two monoclonal antibodies, which together make up the HepeX-B product....See full deal structure in Biomedtracker

Partners: XTL Biopharmaceuticals Ltd. XOMA Corporation

HepeX-B News

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