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UshStat

Sanofi

Drug Names(s): UshStat

Description: UshStat is a gene-based therapy for the treatment of Usher syndrome 1B. The disease is caused by a mutation of the gene encoding myosin VIIA (MY07A), which leads to progressive retinitis pigmentosa combined with a congenital hearing defect. UshStat uses the Company's LentiVector gene delivery technology to deliver a corrected version of the MYO7A gene. A single administration of the product could provide long-term or potentially permanent correction.

Deal Structure: Oxford BioMedica and Sanofi
In April 2009, Oxford BioMedica entered a collaboration with sanofi-aventis to develop four LentiVector-based products for the treatment of ocular diseases, including StarGen. Oxford BioMedica is responsible for preclinical development and for conducting initial Phase I/II studies.

Oxford BioMedica will receive an upfront payment of US$26 million (18 million pounds) and committed funding of up to a further US$24 million (16 million pounds) over three years. In addition, sanofi-aventis has an exclusive option for a worldwide licence to develop and commercialise four ocular products. If successful, Oxford BioMedica will receive further undisclosed license fees, milestone payments and royalties on product sales.

In June 2012, Oxford BioMedica and Sanofi announced that Sanofi elected to exercise its options to acquire two exclusive worldwide licences for further development, manufacture and commercialisation of StarGen and Ushstat.

Under...See full deal structure in Biomedtracker

Partners: Oxford BioMedica plc


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