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H5N1 VLP Vaccine

Mitsubishi Tanabe Pharma Corporation

Drug Names(s): H5 VLP Pandemic Influenza Vaccine

Description: Medicago's H5N1 vaccine was formulated to protect against the avian influenza virus. It is manufactured in Nicotiana benthamiana, a relative of the tobacco plant, using the Company's proprietary VLP technology.

VLPs have several advantages over traditional influenza vaccines. They resemble the virus, allowing them to be recognized readily by the body's immune system, however, they lack the core genetic material making them non-infectious and unable to replicate. Medicago's VLP-based vaccine has shown in preclinical studies it can provide cross- protection against different strains of avian flu, such as the Vietnam and Turkey strains.

Deal Structure: Medicago and Philip Morris
In September 2012, Medicago announced the signing of a licensing agreement with Philip Morris Products SA (PMP), a subsidiary of Philip Morris International Inc. Under the agreement, Medicago grants PMP an exclusive license to develop, commercialize and manufacture Medicago's pandemic and seasonal influenza vaccines for China. Medicago will receive an upfront payment of US$4.5 million from PMP. In addition, Medicago is eligible to receive development milestone payments totalling US$7.5 million, as well as royalty payments on any future sales of pandemic and seasonal influenza vaccines by PMP in China which utilize the Medicago technologies.

Immune Design and Medicago
In June 2013, Immune Design and Medicago entered a license agreement providing Medicago the use and commercialization of Immune Design's proprietary synthetic Toll-like Receptor 4 agonist, Glucopyranosyl Lipid A (GLA). Medicago has the option to use Immune Design's...See full deal structure in Biomedtracker

Partners: Philip Morris International Inc.

H5N1 VLP Vaccine News

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