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HuMax-Inflam

Bristol-Myers Squibb Company

Drug Names(s): MDX-018, HuMax-IL8, HuMax-IL-8

Description: HuMax-Inflam is a high affinity fully human IgG1,k antibody directed towards IL-8. IL-8 is a mediator of inflammation, a chemoattractant for white blood cells called neutrophils, as well as a factor in angiogenesis. HuMax-Inflam blocks binding of IL-8 to neutrophils and inhibits neutrophils from migrating towards sites of inflammation via a process known as chemotaxis. HuMax-Inflam also inhibits IL-8 induced neutrophil activation. In pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice.

Deal Structure: Genmab and Medarex
In June 2001, Genmab and Medarex entered into a collaboration agreement to develop HuMax-Inflam. Under the agreement, the parties will share the cost associated with the pre-clinical and clinical development of the product and will share the commercialization rights and royalties.

Under the collaboration with Genmab on HuMax-Inflam, Medarex has the right to 100% of all revenues and profits in Asia. Outside of Asia, Medarex and Genmab share in the revenues and profits on a 50/50 basis, subject to certain payments that Genmab owes Medarex with respect to milestones and royalties on MDX-018.

Bristol-Myers and Medarex
In July 2009, Bristol-Myers Squibb and Medarex announced that the companies signed a definitive merger agreement providing for the acquisition of Medarex by Bristol-Myers Squibb, for $16.00 per share in cash.

In September 2009, Bristol-Myers Squibb completed its acquisition of Medarex.

Genmab and...See full deal structure in Biomedtracker

Partners: Genmab A/S


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