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BioNumerik Pharmaceuticals, Inc.
Drug Names(s): BNP1350, IND 57250
Description: Karenitecin is a synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.
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