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Pramiconazole

GlaxoSmithKline plc

Drug Names(s): Azoline, R126638

Description: Pramiconazole belongs to the Triazole family of antifungals. Triazoles inhibit fungal cytochrome P450, block demethy lation of lanosterol, causing ergosterol depletion and accumulation of toxic sterols in the membrane.

Deal Structure: In June 2008, Barrier Therapeutics announced that it has signed a definitive merger agreement with Stiefel Laboratories.

In April 2009, GlaxoSmithKline and Stiefel Laboratories announced that they have signed an agreement under which GSK will acquire Stiefel in a deal valued at up to $3.6 billion. GSK's existing prescription dermatological products will be combined with Stiefel's and the new specialist global business will operate under the Stiefel identity within the GSK Group. The acquisition was completed in July 2009.


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