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Drug Names(s): ZYGK1
Description: ZYGK1 is an orally administered small molecule glucokinase activator. Glucokinase (GK) is the enzyme that acts as a glucose sensor in the pancreas and regulates glucose metabolism in the liver. When, circulating glucose levels rise above a certain threshold, the glucokinase enzyme enhances insulin release from pancreas and decreases glucose production in liver. In normal individuals, the pancreas secrete insulin in response to increased levels of glucose in the blood. In patients with Type 2 diabetes, there is a reduction of GK activity in the pancreas and the liver.
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