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Valeant Pharmaceuticals International, Inc.

Drug Names(s): efinaconazole, KP-103, IDP-108

Description: IDP-108 is a topical triazole antifungal.

Triazole antifungals inhibit the fungal cytochrome P450 enzyme 14alpha-demethlyase, thus preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane.

Deal Structure: IDP-108 was licensed by Dow Pharmaceutical Sciences from Kaken Pharmaceuticals.

In January 2010, Valeant acquired Dow Pharmaceutical Sciences. Dow Pharmaceutical will operate as a wholly owned subsidiary of Valeant. Kaken retained rights to the compound in Japan.

Partners: Kaken Pharmaceutical Company, Ltd

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