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Drug Names(s): Exemestane
Description: Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to thenatural substrate androstenedione. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.
Pink Sheet Approval In Brief
Pink Sheet P&U Aromasin
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