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Johnson & Johnson
Drug Names(s): SCIO 469
Description: SCIO-469 inhibits p38 MAP kinase, a stimulatory modulator of pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), IL-1, and cyclooxygenase-2 (COX-2), all of which are known to contribute to both symptoms and disease progression in patients with RA. Preclinical data demonstrated that oral SCIO-469 leads to suppression of induced TNF-alpha levels over a wide range of doses.
Existing protein-based products that antagonize TNF-alpha are prescription products administered only through injection or infusion, and they represent a multi-billion dollar annual market in the United States. If approved, SCIO-469 would be one of the first mechanism-specific oral products aimed at reducing TNF-alpha.
Deal Structure: SCIO-469 is developed by Scios, a member of the Johnson & Johnson Family of Companies.
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