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GTx, Inc.

Drug Names(s): GTx-024, MK-2866, Ostarine

Description: Ostarine is a nonsteroidal SARM that is designed to have positive anabolic effects without having an impact on the prostate and is being developed for andropause as well as other conditions associated with aging, such as sarcopenia.

Deal Structure: In November 2007, GTx and Merck announced an agreement providing for a research and development and global strategic collaboration for selective androgen receptor modulators (SARMs). This collaboration includes GTx's Ostarine and establishes a broad SARM collaboration under which GTx and Merck will pool their programs and partner to discover, develop, and commercialize current as well as future SARM molecules. As part of this global agreement, Merck will be responsible for all future costs associated with ongoing development and, if approved, commercialization of Ostarine and other investigational SARMs resulting from the collaboration.

Under the terms of the collaboration agreement and related stock purchase agreement, GTx and Merck will combine their respective SARM research programs. GTx will receive an upfront payment of $40 million plus $15 million in research reimbursements to be paid over the initial three years of the collaboration. In addition, Merck will make an equity...See full deal structure in Biomedtracker

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