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Oral Palifosfamide

ZIOPHARM Oncology, Inc.

Drug Names(s): Oral palifosfamide, Oral Zymafos, Oral ZIO-201

Description: Ziopharm is developing an oral formulation of palifosfamide for pediatric and outpatient use. Please see Zymafos for the IV formulation.

Palifosfamide is a stabilized IPM (isophosphoramide mustard). IPM is a proprietary stabilized metabolite of ifosfamide. Ifosfamide is a structural analogue of cyclophosphamide and its mechanism of action is presumed to be identical. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. Phosphoramide mustard forms DNA crosslinks between and within DNA strands. This leads to cell death.

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