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Drug Names(s): TRV130, TRV130A
Description: TRV130 is a novel, biased ligand that targets the mu-opioid receptor to optimize analgesia while minimizing mu opioid receptor-mediated side effects such as respiratory suppression and constipation. As a biased ligand, TRV130 activates the G-protein signaling pathway mediated by the mu-opioid receptor while antagonizing the beta-arrestin pathway.
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