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OrbeShield

Soligenix, Inc.

Drug Names(s): Oral beclomethasone 17,21-dipropionate (oral BDP), SGX202, oral beclomethasone dipropionate

Description: BioMedTracker has separate drug profiles for beclomethasone. Please also see orBec, SGX201, and SGX203.

SGX202 is formulated for oral administration in gastrointestinal acute radiation syndrome (GI ARS) patients as a single product consisting of two tablets; one tablet is intended to release beclomethasone dipropionate (BDP), a glucocorticoid, in the proximal portions of the GI tract, and the other tablet is intended to release BDP in the distal portions of the GI tract. Glucocorticoids have potent anti-inflammatory and immunosuppressive properties. This is particularly evident when they are administered at pharmacologic doses, but also is important in normal immune responses. As a consequence, glucocorticoids are widely used as drugs to treat inflammatory conditions such as arthritis or dermatitis, and as adjunction therapy for conditions such as autoimmune diseases.

SGX202 has the potential to reduce the inflammatory cytokine storm induced by the radiation damaged GI tract. The GI tract is extremely sensitive to radiation injury. GI damage is the major cause of rapid mortality during high dose radiation exposure, such as could be encountered during nuclear accidents or with the use of dirty bombs. Gut injury from high dose radiation is associated with epithelial cell damage and hypoperfusion of the intestine, which stimulates a vigorous local and systemic inflammatory response.


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