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Zolmitriptan ODF

APR Applied Pharma Research SA

Drug Names(s): Zolmitriptan Oral Dispersable Film (ODF)

Description: The Zolmitriptan ODF is a very thin polymeric film strip with a size of 3 cm2 and 6 cm2 for the 2.5 mg and 5 mg dosage strengths, respectively. Once placed in the mouth, the ODF dissolves in a few seconds and is swallowed with the saliva without the need of water.

Zolmitriptan is a triptan that binds with high affinity to human recombinant 5-HT1D and 5-HT1B receptors. Zolmitriptan exhibits modest affinity for 5-HT1A receptors, but has no significant affinity (as measured by radioligand binding assays) or pharmacological activity at 5-HT2, 5-HT3, 5-HT4, alpha1-, alpha2- or beta1-adrenergic; H1, H2, histaminic; muscarinic; dopamine1, or dopamine2 receptors. The N-desmethyl metabolite also has high affinity for 5-HT1B/1D and modest affinity for 5-HT1A receptors.

Deal Structure: Zolmitriptan ODF was developed by APR and Labtec in collaboration with Monosol Rx.

Partners: MonoSol Rx Tesa SE


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