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Aker ASA

Drug Names(s): AKR963, omega-3-acid ethyl esters A

Description: ARK963 is an omega-3 based prescription drug candidate. The mechanism of action of omega-3 poly-unsaturated FAs is not completely understood, and may include: inhibition of acyl CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal b-oxidation in the liver, decreased lipogenesis in the liver (eg by acting as poor substrates for the enzymes responsible for TG synthesis), and increased plasma lipoprotein lipase activity. Gene transcription factors may also be involved in the drug's mechanism, including PPAR, SREBP-1, and ChREBP.

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