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Drug Names(s): AC3056
Description: Preclinical investigation demonstrates that AC3056 has favorable effects at the level of various biochemical mediators of the atherosclerotic process. In various animals, the agent reduces serum low density lipoproteins (LDLs), but not serum high density lipoproteins (HDLs), inhibits lipoprotein oxidation, and inhibits cell adhesion molecules in vascular cells. Orally active, its antioxidant effects and effects at the level of lipoproteins inhibited atherosclerotic plaque formation in relevant arterial walls and prevented cholesterol-precipitated functional damage to blood vessels.
Deal Structure: AC3056 was originally in-licensed from Aventis.
In the second quarter of 2005, Amylin terminated its collaboration agreement with Sanofi-Aventis for AC3056 and all rights to that compound reverted to Sanofi-Aventis.
Pink Sheet In Brief: BASF
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