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HGS-TR2J

GlaxoSmithKline plc

Drug Names(s): mAB to TRAIL Receptor 2 - TR2J

Description: HGS-TR2J (TRAIL-R2 mAb) is an agonistic human monoclonal antibody that specifically binds to the TRAIL Receptor-2 protein. TRAIL Receptor 2 often is referred to as a “death receptor” because of its ability to cause apoptosis (programmed cell death) in tumor cells when it is triggered by the natural ligand TRAIL (tumor necrosis factor apoptosis-inducing ligand) . Preclinical studies demonstrate that HGS-TR2J specifically binds TRAIL Receptor 2, induces apoptosis and has anti-tumor activity, both as a single agent and in combination with chemotherapy.

Deal Structure: In July 2012, GlaxoSmithKline and Human Genome Sciences entered into a definitive agreement under which GSK will acquire HGS for US$14.25 per share in cash. The acquisition was completed in August 2012.


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