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Aceon

Symplmed Pharmaceuticals LLC

Drug Names(s): Perindopril Erbumine, Coversyl

Description: Aceon belongs to a family of drugs called angiotensin converting enzyme (ACE) inhibitors. They work by preventing angiotensin I from converting into a more potent form that increases salt and water retention in the body and constricts blood vessels, though other mechanisms, such as inhibiting the degradation of the vasodilator bradykinin, may be involved in their longer term effects. Some ACEIs, including Aceon, have also been found to reduce cardiovascular events in patients with elevated risk.

Deal Structure: CV Therapeutics and Solvay Pharmaceuticals entered into a co-promotion agreement for ACEON in December 2004. The co-promotion agreement covers the United States and extends through at least 2010. CV Therapeutics is responsible for brand marketing activities and has established a cardiovascular specialtysales force to promote the product. Solvay Pharmaceuticals continues to handlethe manufacturing and distribution of the product, and its primary care salesforce also continues to promote the product.

Solvay Pharmaceuticals will book all sales of ACEON and CV Therapeutics will receive a royalty in the approximate range of 50% to 60% on all sales above a pre-specified baseline level of sales. This baseline approximates the current annual sales level of ACEON , which is in the range of $30 million. There are no upfront payments by either party associated with the co-promotion agreement.

On October 11, 2006 CV Therapeutics announced that it has sent Solvay Pharmaceuticals a...See full deal structure in Biomedtracker

Partners: AbbVie Inc. XOMA Corporation


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