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Merck & Co., Inc.

Drug Names(s): Imipenem (MK-0787) + Cilastatin (MK-0791)

Description: Primaxin is a combination of Imipenem (a carbapenem antibiotic) and cilastatin (a dehydropeptidase I inhibitor that blocks degradation of imipenem to a nephrotoxic metabolite in the kidneys).

Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Members of this class exhibit good activity against methicillin-sensitive Staphylococcus aureus, streptococci, anaerobes, enteric Gram-(-) rods (including strains that produce extended spectrum beta lactamases), Pseudomonas, and Acinetobacter. Moderate activity is observed against enterococci, and relatively modest activity against methicillin-resistant S. aurus and penicillin-resistant streptococci.

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