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Roche Holding AG

Drug Names(s): ceftriaxone sodium

Description: Rocephrin is a third generation cephalosporin antibiotic. Third generation cephalosporins have greater Gram-(-) activity than first or second generation cephalosporins. Good activity is observed against streptococci and enteric Gram-(-) rods. Moderate activity is observed against methicillin sensitive strains of Staphyloccocus aureus, and relatively modest activity against Pseudomonas, anaerobes, and methicillin-resistant S. aureus.

Third generation cephalosporins are among the antibiotic classes most strongly associated with Clostridium difficile associated diarrhea.

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