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Synercid

Pfizer Inc.

Drug Names(s): quinupristin and dalfopristin

Description: Synercid, the first streptogramin—the first new antibiotic class available to the United States medical community in over a decade. Synercid exhibits good activity against methicillin-sensitive and -resistant Staphylococcus aureus, streptococci, and Enterococcus faecium (including vanocomycin-resistant strains); and poor activity against Enterococcus faecalis and Gram-(-) bacteria.

Synercid is an injectable formulation of 2 streptogramin (Quinupristin and Dalfopristin) antibiotics. These 2 components act synergistically to kill bacteria by inhibiting bacterial ribosomes involved in protein synthesis. Dalfopristin has been shown to inhibit the early phase of protein synthesis while Quinupristin inhibits the late phase of protein synthesis.

Deal Structure: In October 2010, Pfizer and King Pharmaceuticals announced that they have entered into a definitive merger agreement. In February 2011, Pfizer completed its acquisition of King.


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