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Novartis AG

Drug Names(s): olopatadine ophthalmic solution (0.1%), Opatanol

Description: BioMedTracker has separate drug profiles for Patanol (0.1% olopatadine) and Pataday (0.2%). Please also see Pataday.

Olopatadine is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H1-antagonist that inhibits in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamind induced effects on human conjunctival epithelial cells. Olopatadine is devoid of effects on alpha-adrenergic, dopamine, and muscarinic type 1 and 2 receptors.

Deal Structure: Patanol was originally developed by Alcon.

In 1993, Alcon entered into its initial partnership with Kyowa Hakko, to license olopatadine. The partnership with Kyowa Hakko was expanded in 2006 to include joint promotion of olopatadine in Japan.

In January 2010, Novartis and Nestl initiated completion of the 2008 agreement, whereby Novartis is exercising its call option to acquire Nestl's remaining 52% Alcon stake for USD 28.1 billion, or USD 180 per share. In combination with the 25% stake initially purchased in April 2008, this acquisition gives Novartis 77% ownership of Alcon. To attain a 100% ownership of Alcon, Novartis proposed to acquire the remaining 23% held by minority shareholders, at a fixed exchange ratio of 2.80 Novartis shares for each remaining Alcon share. In August 2010, Novartis announced that it completed its purchase of Alcon stock from Nestle resulting in 77% ownership of Alcon.

In December 2010, Novartis announced that it entered into a definitive...See full deal structure in Biomedtracker

Partners: Kyowa Hakko Kirin Co., Ltd.

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