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Celldex Therapeutics, Inc.
Drug Names(s): TM-27
Description: The overexpression of certain V genes in myelin basic protein (MBP)-specific T cells from MS patients have led to immunotherapies targeting single T-cell Receptors (Vbeta5.2, Vbeta6.1).
ATM027 is a human monoclonal antibody againts the Vbeta5.2/5.3 T cell receptor. Expansion of Vbeta5.2/5.3(+) T cells has been demonstrated in the peripheral blood, cerebrospinal fluid, and brain lesions of MS patients.
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