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PhaseBio Pharmaceuticals, Inc.

Drug Names(s): oxyntomodulin analogue

Description: Oxymera is a recombinant analogue of oxyntomodulin genetically fused with an ELP biopolymer and manufactured in E. coli. This formulation increases metabolic rate and energy expenditure, with improved half-life for reduced dosing frequency.

Oxyntomodulin is thought to act as both a GLP-1 and glucagon agonist. While glucagon agonism can counteract the glucose lowering effects of GLP-1, weight loss from glucagon agonism may counteract this to lead to further lowering of glucose.

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