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Bezlotoxumab

Merck & Co., Inc.

Drug Names(s): CDB-1, MBL-CDB1, MDX-1388, MK-6072, Zinplava

Description: MK-6072 is a fully human antibody developed to target and neutralize the effects of Toxin B, a toxin produced by the bacterium C. difficile.

MK-6072 is also being developed in a fixed dose combination with MK-3415, seen here.

Deal Structure: CDA-1 and CDB-1 were co-developed by Medarex and Massachusetts Biologic Laboratories (MBL).

In April 2009, Merck & Co, Medarex, and MBL of the University of Massachusetts Medical School (UMMS) announced that they signed an exclusive worldwide license agreement for CDA-1 and CDB-1 (also known as MDX-066/MDX-1388 and MBL-CDA1/MBL-CDB1). Under the terms of the agreement, Merck gains worldwide rights to develop and commercialize CDA-1 and CDB-1. Medarex and MBL will receive an upfront payment of $60 million and are potentially eligible to receive additional cash payments up to $165 million upon achievement of certain milestones associated with the development and approval of a drug candidate covered by this agreement. Upon commercialization, Medarex and MBL will also be eligible to receive double-digit royalties on product sales and milestones if certain sales targets are met. In accordance with the co-development agreement between Medarex and MBL, all payments will be divided...See full deal structure in Biomedtracker

Partners: Bristol-Myers Squibb Company


Bezlotoxumab News


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