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Drug Names(s): Zidovudine, AZT, ZDV
Description: Retrovir (Zidovudine, formerly called azidothymidine or AZT) is a pyrimidine nucleoside analogue active against human immunodeficiency virus (HIV). Within cells, zidovudine is converted to the active metabolite, zidovudine 5-triphosphate (AztTP), which inhibits the activity of the HIV reverse transcriptase both by competing for utilization with the natural substrate, deoxythymidine 5-triphosphate (dTTP), and by its incorporation into viral DNA.
Deal Structure: In April 2009, GlaxoSmithKline and Pfizer announced that the Companies have entered into an agreement to create a new HIV company (ViiV) focused solely on research, development and commercialisation of HIV medicines. Upon completion of the transaction, GSK will hold an 85% equity interest in the new company and Pfizer will hold 15% reflecting the value of their currently marketed products. To reflect the potential future performance of their respective HIV pipeline products, GSK and Pfizer have agreed a structure for their equity interests to be adjusted in the event that specified sales and regulatory milestones are achieved.
On November 3rd, 2009, GlaxoSmithKline (GSK) announced the official launch of ViiV Healthcare established by GSK and Pfizer (PFE). The transaction was completed on October 30th 2009.
Partners: Pfizer Inc.
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