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NK4 (Gene Therapy)

Kringle Pharma, Inc.

Drug Names(s): NK4 (Gene Therapy)

Description: Kringle is developing NK4 as a gene and protein therapy.

NK4 is a competitive antagonist of the HGF/cMet interaction. It is composed an N-terminal hairpin domain and four K-domains from HGF. Thus, it contains the cMet receptor binding domain but lacks biological activity. That is, it displaces HGF binding to cMet receptor but does not activate the receptor.


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