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Drug Names(s): LY317615
Description: LY317615 (Enzastaurin) is an orally available potent inhibitor of Protein Kinase C beta. The beta isoform lies in the signal cascade of VEGF and inhibition of this pathway may lead to a block in tumor angiogenesis and growth.
In addition to blocking PKC beta, LY317615 has shown inhibitory activity of other intracellular signaling proteins that are important to the regulation of cellular proliferation and apoptosis, including the Akt pathway. Furhtermore, at concentrations that are reached or exceeded in clinical trials, LY317615 was shown to inhibit the activity of other PKC isoforms in addition to PKC beta.
Eli Lilly and Denovo
In September 2014, Denovo announced that it has acquired enzastaurin, a late-stage oncology drug, from Eli Lilly and Company. Denovo gains all rights to develop, manufacture and commercialize enzastaurin globally, including transfer of all intellectual property and other rights, data, and information. enovo plans to screen for appropriate patient subsets for enrollment in future clinical trials that the company plans to conduct.
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