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ZFP TF - Huntingtin Repressor

Sangamo Biosciences, Inc.

Drug Names(s): ZFP TF - Huntingtin Repressor

Description: The ZFP TF - Huntingtin repressor uses Zinc-Finger Protein technology to achieve allele-specific repression of the huntingtin gene.

Deal Structure: Sangamo and Shire
Shire and Sangamo announced that they have entered into a collaboration and license agreement to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo's zinc finger DNA-binding protein (ZFP) technology.

Shire will receive exclusive world-wide rights to ZFP Therapeutics designed to target four genes (for blood clotting Factors VII, VIII, IX and X) which will be used to investigate curative therapies for hemophilia A and B. Shire also receives the right to designate three additional gene targets. Sangamo is responsible for all activities through submission of Investigational New Drug (IND) Applications and European Clinical Trial Applications (CTA) for each product and Shire will reimburse Sangamo for its internal and external research program-related costs. Shire is responsible for clinical development and commercialization of products arising from the alliance. Shire will pay Sangamo $13 million upfront followed by...See full deal structure in Biomedtracker

Partners: Shire Pharmaceuticals Group PLC


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