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Doribax

Johnson & Johnson

Drug Names(s): doripenem, S-4661, Finibax (Japan)

Description: Doribax is a carbapenem antibiotic.

Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Members of this class exhibit good activity against methicillin-sensitive Staphylococcus aureus, streptococci, anaerobes, enteric Gram-(-) rods (including strains that produce extended spectrum beta lactamases), Pseudomonas, and Acinetobacter. Moderate activity is observed against enterococci, and relatively modest activity against methicillin-resistant S. aureus and penicillin-resistant streptococci.

Deal Structure: On April 19, 2005, Johnson & Johnson announced that its Ortho-McNeil Pharmaceutical unit will acquire Peninsula Pharmaceuticals Inc., a privately held antibiotic developer, for $245 million in cash.

Peninsula Pharmaceuticals and Shionogi & Co. reached a licensing agreement in May 2003 for Doribax. Peninsula has obtained exclusive rights including sublicense rights to develop and market doripenem in North America; Shionogi will manufacture the product forworldwide distribution.

Partners: Shionogi & Co. Ltd.


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