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Sangamo Biosciences, Inc.

Drug Names(s): EW-A-401, ZFP Therapeutic, VEGF activator zinc finger protein

Description: SB-509 is an injectable formulation of plasmid DNA that encodes a zinc finger DNA-binding protein transcription factor (ZFP TFTM), designed to upregulate the vascular endothelial growth factor A (VEGF-A) gene.

VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model, SB-509 has proven effective in protecting motor and sensory nerve function from disease-induced nerve damage.

Deal Structure: In December 2006, Edwards Lifesciences and Sangamo BioSciences entered into a definitive asset purchase agreement under which Sangamo acquired Edwards' angiogenesis program. Sangamo acquired two clinical stage programs in peripheral vascular disease (PAD) and a late stage pre-clinical program in ischemic heart disease (IHD).

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