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JZP-386

Jazz Pharmaceuticals plc

Drug Names(s): C-10323, deuterium-modified sodium oxybate, D-SXB

Description: C-10323 is a deuterium-modified sodium oxybate developed through Concert's DCE Platform (Deuterated Chemical Entity). Sodium oxybate is the active ingredient in Xyrem.

Concert's DCE Platform involves selective deuterium modification to existing compounds which usually have less than ideal ADME profiles. This platform has the potential to improve ADME without altering desirable pharmacological properties.

Deal Structure: Concert and Jazz
In February 2013, Concert and Jazz entered into an exclusive license agreement that provides Jazz worldwide rights to develop and commercialize Concert's deuterium-modified sodium oxybate (D-SXB) compounds, including C-10323. Under the agreement, Jazz will have worldwide commercial rights to C-10323, as well as principal responsibility for ongoing development activities. Concert will receive an upfront payment and is eligible to receive additional milestone payments as well as tiered royalties based on potential worldwide sales of any D-SXB products.

Partners: Concert Pharmaceuticals, Inc.


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