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Comtan

Novartis AG

Drug Names(s): Comtess, entacapone

Description: Comtan (Entacapone) inhibits peripheral catechol-O-methyltransferase (COMT), which breaks down levodopa. When used with an aromatic amino acid decarboxylase inhibitor (to inhibit the other major enzyme metabolizing levodopa peripherally), plasma levels of levodopa are greater and more sustained after administration of levodopa. The effect of Comtan on central COMT is unknown.

Deal Structure: Revenue splits for this drug are BioMedTracker estimates.

In 1996, Sandoz (which then merged with Ciba to become Novartis) licensed Comtan from Orion Pharma and has exclusive marketing rights except in certain Scandinavian/Baltic/Eastern European countries, the UK, Ireland, and Germany.

BioMedTracker groups Stalevo and Comtan revenue together under Stalevo.

Partners: Orion Corporation


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