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Bristol-Myers Squibb Company
Drug Names(s): Carbidopa-Levodopa
Description: Sinemet is a combination of levodopa, a precursor to dopamine, and carbidopa, which inhibits the enzyme DDC from metabolizing levodopa before it reaches the brain. Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase (DDC). This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson's Disease, however, activation of peripheral dopamine receptors causes nausea and vomiting. For this reason levodopa is usually administered in combination with a DOPA decarboxylase inhibitor, in this case carbidopa, which does not cross the blood brain barrier but prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side-effects of levodopa. Use of carbidopa also increases the quantity of levodopa in the bloodstream that is available to enter the brain.
Partners: Merck & Co., Inc.
Pink Sheet Roche/DuPont
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