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Accupril

Pfizer Inc.

Drug Names(s): Quinapril hydrochloride, Accuzide

Description: Accupril (Quinapril) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.

Quinapril inhibits the elevation in blood pressure caused by intravenously administeredangiotensin I, but has no effect on the pressor response to angiotensin II, norepinephrine orepinephrine.


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