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KAI-9803

Bristol-Myers Squibb Company

Drug Names(s): delcasertib

Description: KAI-9803 is a selective inhibitor of the delta variant (isoenzyme) of Protein Kinase C, a modulator of both the apoptosis cascade and mitochondrial damage leading to cellular necrosis in reperfusion injury after a heart attack. It disrupts binding of activated deltaPKC with its RACK (receptor for activated C-kinase).

Deal Structure: KAI and Daiichi Sankyo
In January 2006, KAI Pharmaceuticals and Daiichi Sankyo announced that Sankyo Company, Limited, a wholly owned subsidiary of Daiichi Sankyo, and KAI Pharmaceuticals entered an agreement for the global development and commercialization of KAI-9803. Under the terms of the partnership, Sankyo will make an initial payment to KAI of $20 million. In addition, KAI could receive potential development and commercialization milestones of up to $300 million for two initial indications for KAI-9803, as well as milestone payments for future delta PKC inhibitors. Sankyo will fund all future development, and will have global development and commercialization rights and pay KAI a double-digit royalty on sales.

KAI will have the option to perform certain clinical studies. In North America, KAI will have the right to co-promote products in the acute care/hospital setting. KAI may receive $20 million from Sankyo in research support over five years to identify new...See full deal structure in Biomedtracker

Partners: Amgen, Inc.


KAI-9803 News


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