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Alethia BioTherapeutics Inc.

Drug Names(s): AB-16B5

Description: AB-16B5 is a monoclonal antibody that inhibits metastasis invasion and enhances response to chemotherapy by inhibiting epithelial-to-mesenchymal transition (EMT) and stem cell markers. It targets clusterin (sCLU), a secreted protein which promotes EMT, a key process in metastatic invasion.

Deal Structure: Alethia and IBC Generium
In May 2013, Alethia Biotherapeutics entered into a global strategic alliance with the IBC Generium to jointly develop AB-16B5.

Under the terms of the alliance, Alethia and IBC Generium will collaborate for the ongoing development of AB-16B5 and, upon completion of the initial clinical study, share equally in the downstream economics in territories outside Russia and the CIS states. Alethia will receive an upfront cash payment and R&D funding to conduct the initial clinical study in Canada. In addition to an exclusive license granted to IBC Generium for other territories, IBC Generium has also been granted the right to an exclusive license for Russia and the CIS states for which development milestones and royalties would be payable to Alethia. Further financial terms were not disclosed.

Partners: International Biotechnology Center (IBC) Generium

AB-16B5 News

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