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Bristol-Myers Squibb Company

Drug Names(s): Belatacept, LEA29Y, BMS-224818

Description: Belatacept (LEA29Y), a selective costimulationblocker, is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4. Belatacept was derived from abatacept (Orencia),with only a two amino acid difference. This gives it greater binding affinity for the CD80 and CD86 costimulatory ligands of antigen-presenting cells.

In the context of antigen recognition (signal 1), the interaction of CD80 and CD86 with the surface costimulatory receptor CD28 of T cells(signal 2) is required for full activation of T cells. Blockade of signal 2 inhibitsT-cell activation, promoting anergy and apoptosis.

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