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Juno Therapeutics Inc.

Drug Names(s): T Cell Receptors (TCRs) Program, JTCR-016

Description: T cells with high-affinity TCRs (T cell receptors) are modified with TCR sequences that bind more tightly to a target antigen/HLA complex. Thus, high-affinity TCR-based strategies can target tumor proteins inside the tumor cell. Further, given the association with an individual’s HLA proteins these cells are effective in only those patients who have the specific HLA molecule targeted by the high-affinity TCR.

This TCR T cell product targets WT-1 (Wilms' Tumor Protein-1), an intracellular protein overexpressed on a number of cancers.

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