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Pharmaxis Ltd

Drug Names(s): NCX 1020

Description: NCX 1020 is a nitric oxide-donating derivative of budesonide, a corticosteroid. The addition of a nitric oxide-donating moiety may lead to smooth muscle relaxation and additional inflammation fighting capabilities.

Deal Structure: In October 2005, NicOx S.A. and Topigen Pharmaceuticals announced that they signed a license and development agreement for NicOx's compound, NCX 1020, in Chronic Obstructive Pulmonary Disease (COPD) and other respiratory disorders. NicOx has granted Topigen rights to NCX 1020 in North America, in return for a 2 million euro upfront payment and up to 52.9 million euros in milestones and commercial success fees, in addition to a share in future revenues.

Under the terms of the agreement, Topigen acquires the development and commercialization rights to NCX 1020 in North America with an option to obtain rights to the rest-of-world from NicOx at a later date. Topigen will manage and fund all further development activities, through to product registration, supervised by a joint management committee and NicOx will receive an undisclosed royalty on Topigen's net sales in North America. Should Topigen exercise the option for rest-of-world rights, NicOx will receive payment of an...See full deal structure in Biomedtracker

TPI-1020 News

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