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Japan Tobacco Inc.
Drug Names(s): JTT851, JTT 851
Deal Structure: JTT-851 is a G protein-coupled receptor 40 (FFA1, GPR40) agonist. JTT-851 targets the free fatty acid receptor 1 (FFA1) in the pancreas, activating the receptor to elicit an increase in cytosolic Ca2+ via the phosphoinositide pathway. This increase in Ca2+ results in a signal cascade thus increasing the release of insulin.
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