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Kadmon Holdings, Inc.
Drug Names(s): AAV2hAQP1
Description: Kadmon is developing an Adeno-associated virus vector containing the human aquaporin-1 gene (AAV2hAQP1).
Kadmon and National Institute of Dental and Craniofacial Research
In June 2014, Kadmon and the National Institute of Dental and Craniofacial Research (NIDCR), an institute of the National Institutes of Health, established a Cooperative Research and Development Agreement (CRADA) to develop an Adeno-associated virus vector containing the human aquaporin-1 gene (AAV2hAQP1) for the treatment of xerostomia resulting from the use of ionizing radiation (IR) in the treatment of head and neck cancer.
Under terms of the agreement, Kadmon and NIDCR will conduct a Phase I study to test the safety of single escalating doses of AAV2hAQP1. Effectiveness, measured by increase in parotid gland salivary output post-IR, will also be tested for up to three years.
Partners: National Institute of Dental and Craniofacial Research
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