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AstraZeneca PLC

Drug Names(s): AZD2171, cediranib, Zemfirza

Description: AZD2171 is an oral potent and selective inhibitor of the predominant receptor that drives angiogenesis. There are three VEGF receptors involved in mediating tumour angiogenesis: two, VEGFR-1 (also known as Flt-1) and VEGFR-2 (also known as 'Kinase inert Domain-containing receptor', KDR), are located on the endothelium of the vascular system. A third receptor, VEGFR-3 (also called Flt-4), is expressed on the endothelium of the lymphatic system. AZD2171 is a potent inhibitor of VEGFR-2, the predominant receptor through which VEGF exerts its effect.

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