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Nalbuphine ER

Trevi Therapeutics, Inc.

Drug Names(s): PW4142, T111

Description: Nalbuphine ER is an extended release formulation of nalbuphine (Nubain, an intravenous medication), a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It binds to mu, kappa, and delta opioid receptors, but not to sigma receptors. It is primarily a kappa agonist/partial mu antagonist analgesic.

Deal Structure: Nalbuphine ER was originally developed by Penwest Pharmaceuticals.

Endo and Penwest
In August 2010, Penwest Pharmaceuticals announced that it has entered into a merger agreement under which Endo Pharmaceuticals has agreed to acquire all of the common stock of Penwest for $5.00 per share in cash. The acquisition was completed in November 2010.

Endo and Trevi
In 2011, Trevi acquired the worldwide license from Endo for Nalbuphine ER.

Partners: Endo International plc


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