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MK-0524B

Merck & Co., Inc.

Drug Names(s): MK-0524A (ER niacin/laropiprant) combined with Simvastatin; MK0524B

Description: MK-0524B is MK-0524A combined with simvastatin.

MK-0524A is extended-release niacin combined with a flushing pathway inhibitor (MK-0524), which is a selective antagonist of the DP1 receptor. DP1 is a receptor for the vasodilatory prostaglandin D2, and is also called PGD2 receptor 1.

Simvastatin inhibits HMG-CoA reductase, an enzyme required for the synthesis of cholesterol.


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